Acetylenic aryl sulfonamide and phosphinic acid amide...

Details Acetylenic aryl sulfonamide and phosphinic acid amide... Acetylenic aryl sulfonamide and phosphinic acid amide...

C - Chemistry, Metallurgy

07

C

C07C 311/29 (2006.01) C07C 309/42 (2006.01) C07F 9/36 (2006.01)

Patent

CA 2356855

Hydroxamic acids having formula (B) wherein the variables are as defined herein, are useful in treating disease conditions mediated by TNF-.alpha. such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

L'invention concerne des acides hydroxamiques représentés par la formule (B) dont les variables sont définies dans la description, qui sont utiles pour traiter des affections dans lesquelles intervient TNF-.alpha. telles que la polyarthrite rhumatoïde, l'ostéoarthrite, la septicémie, le SIDA, la rectocolite hémorragique, la sclérose en plaques, la maladie de Crohn et la dégénérescence de cartilage.

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