A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4427 (2006.01) A61K 31/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2611474
The invention is directed to a method of inhibiting FLT3 tyrosine kinase activity or expression or reducing FLT3 kinase activity or expression in a cell or a subject comprising the administration of a farnesyl transferase inhibitor and a FLT3 kinase inhibitor selected from compounds of Formula (I'). Included within the present invention is both prophylactic and therapeutic methods for treating a subject at risk of (or susceptible to) developing a cell proliferative disorder or a disorder related to FLT3.
L'invention concerne un procédé destiné à inhiber l'activité ou l'expression de la tyrosine kinase FLT3 ou de la réduire dans une cellule ou un sujet par administration d'un inhibiteur de farnesyl transférase et d'un inhibiteur de kinase FLT3 choisi parmi les composés de formule (I'). Cette invention concerne également des procédés prophylactiques et thérapeutiques destinés à traiter un sujet à risque (ou susceptible) de développer un trouble à prolifération cellulaire ou un trouble lié au FLT3.
Baumann Christian Andrew
Gaul Michael David
Johnson Dana L.
Tuman Robert W.
Janssen Pharmaceutica N.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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