Senescent cell derived inhibitors of dna synthesis

Details Senescent cell derived inhibitors of dna synthesis Senescent cell derived inhibitors of dna synthesis

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2125974

An expression vector cDNA library derived from senescent cells has been used to isolate cDNA clones that encode inhibitors of DNA synthesis. Such inhibitors play a role in cellular senescence and aging. Antisense nucleic acids reduce the inhibition of DNA synthesis.

On a utilisé une banque d'ADNc dérivée des cellules sénescentes dans un vecteur d'expression afin d'isoler les clones d'ADNc qui codent des inhibiteurs de la synthèse d'ADN. Ces inhibiteurs jouent un rôle dans la sénescence cellulaire et le vieillissement. Des acides nucléiques non codants réduisent l'inhibition de la synthèse d'ADN.

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