Non-peptidic renin inhibitors nitroderivatives

Details Non-peptidic renin inhibitors nitroderivatives Non-peptidic renin inhibitors nitroderivatives

C - Chemistry, Metallurgy

07

D

C07D 211/78 (2006.01) A61K 31/439 (2006.01) A61P 9/12 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 451/02 (2006.01) C07D 451/14 (2006.01) C07D 487/08 (2006.01) C07D 498/08 (2006.01) C07D 513/08 (2006.01)

Patent

CA 2646235

Non-peptidic renin inhibitors nitroderivatives of general formula (I): A1-(Xa-ONO2)j 5 (I) having wider pharmacological activity and enhanced tolerability. They can be employed for treating or preventing cardiovascular, renal and chronic liver diseases, inflammatory processes and metabolic syndrome.

La présente invention concerne des dérivés nitro d'inhibiteurs de rénine non peptidiques de formule générale (I) : A1-(Xa-ONO2)j 5 (I) dont l'activité pharmacologique est élargie et dont la tolérabilité est améliorée. Lesdits dérivés peuvent être employés dans le traitement prophylactique ou thérapeutique de maladies cardio-vasculaires, rénales et hépatiques chroniques, de processus inflammatoires et du syndrome métabolique.

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