Certain aminomethyl phenylimidazole derivatives; a new class...

Details Certain aminomethyl phenylimidazole derivatives; a new class... Certain aminomethyl phenylimidazole derivatives; a new class...

A - Human Necessities

61

K

A61K 31/496 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) C07D 233/54 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2201140

This invention encompasses compounds of formula (I) where R1, R3, R4, R6, X, Y, and Z and T are variables; and M is (a) or (b) where R2 is a variable; or R1 and R2 together may represent -(CH2)n1 where n1 is 1, 2 or 3. These compounds are highly selective partial agonists or antagonists at brain dopamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism. Furthermore, compounds of this invention may be useful in treating the extraparamidyl side effects associated with the use of conventional neuroleptic agents.

L'invention porte sur des composés de formule (I) dans laquelle R¿1?, R¿3? R¿4?, R¿6?, Z et T sont des variables et M est représenté par les formules (a) ou (b) dans lesquelles R¿2? est une variable; ou bien R¿1? et R¿2? peuvent représenter ensemble -(CH¿2?)¿n1? où n1 vaut 1, 2 ou 3. Ces composés sont des agonistes ou antagonistes partiels hautement sélectifs des sous-types du récepteur de la dopamine du cerveau ou de leurs précurseurs, et s'avèrent utiles dans le diagnostic et le traitement de troubles affectifs tels que la schizophrénie et la dépression et de troubles moteurs tels que la maladie de Parkinson. Lesdits composés peuvent en outre s'avérer utiles dans le traitement des effets secondaires extraparamidyliques associés à l'utilisation de neuroleptiques usuels.

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