C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/10 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 25/00 (2006.01) C07D 215/56 (2006.01) C07D 401/14 (2006.01) C07D 405/10 (2006.01) C07D 413/14 (2006.01) C07D 417/10 (2006.01)
Patent
CA 2655787
The present invention is directed to benzyl-substituted quinolone compounds of general formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of diseases in which the M1 receptor is involved.
La présente invention concerne des composés de quinolone à substitution benzyle de formule générale (I) qui sont des effecteurs allostériques positifs du récepteur M1 et qui sont utilisés pour traiter des maladies dans lesquelles le récepteur M1 est impliqué, telles que la maladie d'Alzheimer, la douleur ou les troubles du sommeil. Cette invention concerne également des compositions pharmaceutiques comprenant ces composés, ainsi que l'utilisation de ces composés et de ces compositions pour traiter des maladies dans lesquelles le récepteur M1 est impliqué.
Bunda Jaime Lynn
Lindsley Craig
Shipe William D.
Yang Feng
Merck And Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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