Antibody variants and fragments thereof

Details Antibody variants and fragments thereof Antibody variants and fragments thereof

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/22 (2006.01) C07K 16/28 (2006.01) C07K 16/42 (2006.01) C12N 15/10 (2006.01) C12N 15/13 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2323757

A variant of a polypetide comprising a human IgG Fc region is described, which variant comprises an amino acid substitution at one or more of amino acid positions 270, 322, 326, 327, 329, 331, 333 or 334 of the human IgG Fc region. Such variants display altered effector function. For example, C1q binding and/or complement dependent cytotoxicity (CDC) activity may be altered in the variant polypeptide. The application also discloses a variant of a parent polypeptide comprising a human IgG Fc region, which variant has a better binding affinity for human C1q than the parent polypeptide.

L'invention concerne un variant d'un polypeptide comprenant une région Fc d'IgG humaine, ce variant présentant une substitution d'acide aminé au niveau d'une ou de plusieurs des positions d'acides aminés 270, 322, 326, 327, 329, 331, 333 ou 334 de la région Fc de l'IgG humaine. De tels variants démontrent une fonction effectrice modifiée. Par exemple, l'activité de fixation sur C1q et/ou l'activité de cytotoxicité dépendant du complément peuvent être modifiées dans le polypeptide variant. L'invention concerne également un variant d'un polypeptide parent comprenant une région Fc d'IgG humaine, lequel variant possède une meilleure affinité de fixation sur C1q humain que le polypeptide parent.

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