Antagonistic selective binding agents of osteoprotegerin...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/13 (2006.01) A61K 38/22 (2006.01) A61K 39/395 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2400929

Selective binding agents of osteoprotegerin binding protein (OPGbp) are provided by the invention. More particularly, the invention provides for antibodies and antigen binding domains which selectively bind to OPGbp and may be used to prevent or treat conditions relating to loss of bone mass. Nucleic acid molecules encoding said antibodies and antigen binding domains, and expression vectors and host cells for the production of same are also provided.

La présente invention concerne des agents de liaison sélectifs de protéine de liaison d'ostéoprotégérine (OPGbp). Plus particulièrement, cette invention concerne des domaines de liaison d'anticorps et d'antigènes qui se fixent sélectivement sur les OPGbp et qui peuvent être utilisés pour prévenir ou traiter les états liées à la perte de la masse osseuse. En outre, cette invention concerne des molécules d'acide nucléique codant ces domaines de liaison d'anticorps et d'antigènes, ainsi que les vecteurs d'expression et les cellules hôtes utilisés dans leur production.

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