Cancer specific pcna isoform binding antibodies and uses...

Details Cancer specific pcna isoform binding antibodies and uses... Cancer specific pcna isoform binding antibodies and uses...

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61P 35/00 (2006.01) C07K 16/44 (2006.01) G01N 33/12 (2006.01)

Patent

CA 2605745

Antibodies specifically bind only to a cancer specific proliferating cell nuclear antigen (csPCNA) isoform and not to the non-malignant proliferating cell nuclear antigen (nmPCNA) isoform. Methods and compositions to detect the presence of csPCNA isoform are disclosed.

L'invention porte sur des anticorps qui se lient de manière spécifique uniquement à une isoforme d'un antigène nucléaire des cellules prolifératives cancéreuses spécifiques (PCNAcs) et non à l'isoforme d'un antigène nucléaire des cellules prolifératives non malignes (PCNAnm). L'invention porte également sur des méthodes et sur des compositions visant à détecter la présence d'une isoforme de PCNAcs.

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