Terminal complement inhibitor fusion genes and proteins

Details Terminal complement inhibitor fusion genes and proteins Terminal complement inhibitor fusion genes and proteins

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A01K 67/027 (2006.01) A61K 35/12 (2006.01) C07K 14/03 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2184356

Nucleic acid sequences encoding chimeric proteins that comprise a functional portion of a parent terminal complement inhibitor, such as CD59, and a heterologous transmembrane domain are provided. The parent terminal complement inhibitor is modified to inactivate its GPI signal sequence. The heterologous transmembrane domain serves to anchor the chimeric protein to the cell membrane without substantially interfering with the complement inhibitor activity of the terminal complement inhibitor. The nucleic acid sequences and encoded chimeric proteins can be used to protect cells from complement attack.

Séquences nucléotidiques codant des protéines chimères comprenant une partie fonctionnelle constituée d'un inhibiteur de complément terminal parent tel que le CD59, et un domaine transmembranaire hétérologue. L'inhibiteur de complément terminal est modifié de sorte que sa séquence de signaux GPI soit inactivée. Le domaine transmembranaire hétérologue sert à ancrer la protéine chimère à la membrane de la cellule sans que cela n'affecte l'activité inhibitrice de complément de l'inhibiteur de complément terminal. Les séquences nucléotidiques et les protéines chimères codées peuvent être utilisées pour protéger les cellules contre l'attaque d'un complément.

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