Injectable vaccines against multiple meningococcal serogroups

A - Human Necessities – 61 – K

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A61K 39/095 (2006.01) A61K 39/02 (2006.01) A61K 39/09 (2006.01) A61K 39/39 (2006.01) C07K 14/22 (2006.01)

Patent

CA 2514328

An injectable immunogenic composition comprising capsular saccharides from at least two of serogroups A, C, W135 and Y of Neisseria meningitidis, wherein said capsular saccharides are conjugated to carrier protein(s) and/or are oligosaccharides, and wherein (i) the composition comprises <50 ~g meningococcal saccharide per dose, and/or (ii) the composition further comprises an antigen from one or more of (a) serogroup B N.meningitidis; (b) Haemophilus influenzae type B; and/or (c) Streptococcus pneumoniae. Saccharide antigens in the compositions are generally conjugated to a carrier.

L'invention concerne une composition immunogène injectable contenant des sacharrides capsulaires provenant d'au moins deux sérogroupes A, C, W135 et Y de Neisseria meningitidis, les sacharrides capsulaires étant conjugués à une ou des protéine(s) porteuse(s) et/ou étant des oligosaccharides. La composition comporte (i) < 50 µg de sacharride méningocoque par dose, et/ou la composition comprend en outre (ii) un antigène provenant d'un ou plusieurs des éléments suivants (a) sérogroupe B N.meningitidis; (b) Haemophilus influenzae type B; et/ou (c) Streptococcus pneumoniae. Les antigènes de sacharrides contenus dans les compositions sont normalement conjugués à un porteur.

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