Microbial production of actinol

Details Microbial production of actinol Microbial production of actinol

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01) C12P 7/26 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2280350

A process for the manufacture of (4R, 6R)-4-hydroxy-2,2,6-trimethyl- cyclohexanone comprises contacting (6R)-2,2,6-trimethylcyclohexanedione with a microorganism which is selected from the group consisting of microorganisms of the genera Cellulomonas, Corynebacterium, Planococcus and Arthrobacter and which is capable of the selective asymmetric reduction of (6R)-2,2,6-trimethylcyclohexanedione to (4R, 6R)-4-hydroxy-2,2,6-trimethyl- cyclohexanone, and recovering the resulting (4R, 6R)-4-hydroxy-2,2,6- trimethylcyclohexanone from the reaction mixture. The selective asymmetric reduction can be effected in the presence of a co-factor such as nicotinamide adenine dinucleotide (NAD), nicotinamide adenine dinucleotide phosphate (NADP), or said co-factor with glucose and glucose dehydrogenase (GDH), and/or in the presence of a surfactant. The product is useful for the synthesis of carotenoids such as zeaxanthin.

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