Novel methods for ester detoxication

Details Novel methods for ester detoxication Novel methods for ester detoxication

A - Human Necessities

61

K

A61K 38/46 (2006.01) C12N 9/18 (2006.01) C12N 15/10 (2006.01) C12N 15/55 (2006.01) C12Q 1/42 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2659097

This invention relates to a method for detoxication of inorganic or organic esters including OP nerve agents, cocaine, and respective analogs. More specifically, this invention pertains to the treatment of potentially neurotoxic esters or other ester groups by elaborating a more effective hydrolytic enzyme for therapeutic application. The structures of the synthesized OP analogs are provided. This invention also provides a diagnostic method and an Array Biosensor for detecting OP agents in biological and environmental samples.

La présente invention concerne une méthode de désintoxication d'esters inorganiques ou organiques, y compris des agents neurotoxiques OP, la cocaïne et leurs analogues respectifs. Plus spécifiquement, la présente invention concerne le traitement d'esters potentiellement neurotoxiques ou d'autres groupements esters par élaboration d'une enzyme hydrolytique plus efficace dans le cadre d'un traitement thérapeutique. La présente invention englobe les structures des analogues OP synthétisés. La présente invention concerne également une méthode de diagnostic et un biodétecteur à réseaux pour la détection d'agents OP dans des échantillons biologiques et environnementaux.

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