Method and apparatus for assessing neural function by sparse...

A - Human Necessities – 61 – B

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A61B 10/00 (2006.01) A61B 3/00 (2006.01) A61B 5/00 (2006.01) A61B 5/04 (2006.01) A61B 5/0484 (2006.01) A61B 19/00 (2006.01)

Patent

CA 2404617

A method and an apparatus are described for simultaneously assessing the functional status of component parts of the nervous system by presenting sparse stimuli to one or more parts of the sensory nervous system. Sparse stimuli consist of temporal sequences of stimulus conditions presented against a baseline null stimulus condition, where the non-null stimulus condition, or conditions, are presented relatively infrequently. The low probability of encountering a stimulus differing from a baseline or null stimulus condition in sparse stimulus sequences insures that gain control mechanisms within the nervous system will increase the neural response magnitude and also bias the measured responses to those neurone populations having such gain controls. The con- sequently increased response amplitudes ensure more reliably recorded responses than are obtained with non-sparse stimuli.

L'invention concerne une méthode et un appareil destinés à évaluer de manière simultanée le statut fonctionnel de parties constituant le système nerveux par présentation de stimuli épars à une ou plusieurs parties du système nerveux sensoriel. Ces stimuli épars se caractérisent par des séquences temporelles de conditions de stimuli présentées contre une condition de stimulus nul de ligne de base, la ou les condition(s) de stimuli non nuls étant présentée(s) de manière relativement peu fréquente. La faible probabilité de rencontrer un stimulus différent d'une condition de stimulus nul ou de ligne de base dans des séquences de stimuli épars garantit que les mécanismes de régulation de gain à l'intérieur du système nerveux augmentent l'amplitude des réponses neuronales et polarisent les réponses mesurées vers les populations de neurones présentant ces régulations de gain. Les amplitudes de réponse ainsi augmentées garantissent l'obtention de réponses enregistrées plus fiables que celles obtenues avec des stimuli non épars.

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