C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/867 (2006.01) A61K 35/14 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2484223
A method of treating brain disorders involving loss of cells that respond to GDNF is disclosed. In one embodiment, the invention comprises the steps of (a) transducing human neural stem cells with glial-derived neurotrophic factor (GDNF), wherein the GDNF gene is under control of an inducible promoter system, and (b) transplanting the transduced cells into the brain of a patient.
L'invention concerne un procédé de traitement de troubles cérébraux impliquant une perte de cellules qui réagissent au GDNF. Dans un mode de réalisation, il est procédé (a) à la transduction de cellules souches neuronales humaines avec le facteur de croissance neurotrophique issu des cellules gliales (GDNF), le gène GDNF étant sous contrôle d'un système promoteur inductible, et (b) à la transplantation des cellules transduites dans le cerveau du patient.
Mccarthy Tetrault Llp
Svendsen Clive N.
Wisconsin Alumni Research Foundation
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