C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/06 (2006.01) A61K 31/4025 (2006.01) A61P 19/00 (2006.01) A61K 31/4015 (2006.01) C07D 207/26 (2006.01)
Patent
CA 2429850
This invention is directed to EP4 receptor selective prostaglandin agonists of the Formula (I), wherein R2, X, Z and Q are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds. This invention is also directed to methods of treating conditions which present with low bone mass, particularly osteoporosis, frailty, an osteoporotic fracture, a bone defect, childhood idiopathic bone loss, alveolar bone loss, mandibular bone loss, bone fracture, osteotomy, bone loss associated with periodontitis, or prosthetic ingrowth in a mammal comprising administering those compounds.
L'invention concerne des agonistes de prostaglandine sélectifs au récepteur EP4 représentés par la formule (I), dans laquelle R?2¿, X, Z et Q sont tels que définis dans le descriptif. L'invention concerne par ailleurs des compositions pharmaceutiques contenant ces composés. De plus, l'invention concerne des méthodes de traitement de pathologies caractérisées par une faible masse osseuse, en particulier l'ostéoporose, la fragilité, les fractures ostéoporotiques, l'érosion osseuse, la perte osseuse idiopathique chez l'enfant, la perte osseuse alvéolaire, la perte osseuse mandibulaire, les fractures osseuses, l'ostéotomie, la perte osseuse associée à la parodontite, ou à l'excroissance prothétique chez les mammifères, consistant à administrer ces composés.
Cameron Kimberly 0'keefe
Lefker Bruce Allen
Pfizer Products Inc.
Smart & Biggar
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