Carboxyl acid substituted heterocycles as metalloproteinase...

C - Chemistry – Metallurgy – 07 – D

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C07D 223/12 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2315826

The present invention relates to metalloproteinase inhibitor, of formula (I) or a pharmaceutically acceptable salt thereof for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of inflammation, tissue degradation and related diseases. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

L'invention concerne des inhibiteurs de métalloprotéase de la formule (I) ou un sel pharmaceutiquement acceptable desdits inhibiteurs, qui conviennent pour des procédés prophylactiques ou de traitement d'une inflammation, de la dégénération tissulaire, du cancer, de la fibrose et de maladies associées. L'invention concerne en outre de nouveaux composés, analogues, promédicaments et sels pharmaceutiquement acceptables desdits composés, des compositions pharmaceutiques et des procédés prophylactiques ou de traitement d'une inflammation, de la dégénération tissulaire et de maladies associées. L'invention concerne enfin des procédés de production desdits composés ainsi que des intermédiaires s'utilisant efficacement dans lesdits procédés.

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