Sustained release formulations

Details Sustained release formulations Sustained release formulations

A - Human Necessities

61

K

A61K 9/32 (2006.01) A61K 9/50 (2006.01) A61K 31/65 (2006.01)

Patent

CA 2047861

Abstract Semi-enteric controlled release formulations are comprised of a biological active agent such as an antibiotic that is blended with a water-soluble bulking agent, the mix then coated onto an inert core. The coated active core is further coated with a mixture comprised of an acrylic copolymer, bulking agent and pH dependent food acid. These different coating components possess different solubility characteristics which result in a gradual release of the active in both the stomach and small intestine that provides an increased bioavailability of the active drug. DA8R9009.DOC 7/11/90 #29-1

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