Oral polymeric membrane feruloyl esterase producing bacteria...

A - Human Necessities – 61 – K

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Details

A61K 35/66 (2006.01) A23C 13/16 (2006.01) A23C 19/00 (2006.01) A23G 9/36 (2006.01) A23L 1/30 (2006.01) A61K 9/08 (2006.01) A61K 9/20 (2006.01) A61K 31/192 (2006.01) A61P 1/16 (2006.01) A61P 3/06 (2006.01) A61P 3/08 (2006.01) C12N 9/16 (2006.01)

Patent

CA 2662710

The present invention relates to an oral formulation to lower serum or hepatic lipid and triglyceride concentrations, hepatic inflammation and/or insulin resistance in a patient comprising live feruloyl esterase producing microorganisms alone or in association with a pharmaceutically acceptable carrier resistant to gastric conditions, and wherein the microorganisms are wild type, genetically modified, or combination thereof. The present invention is also directed to an oral formulation to lower serum or hepatic lipid and triglyceride concentrations, hepatic inflammation and/or insulin resistance in a patient, which comprises polymeric microcapsules containing live feruloyl esterase producing microorganisms in suspension in a pharmaceutically acceptable carrier, wherein said microcapsules are semipermeable and resistant to gastro-intestinal conditions, and wherein said microorganism are wild type, genetically modified, or combination thereof as well as methods of preventing or improving liver diseases and disorders and uses thereof.

La présente invention concerne une formulation orale conçue pour réduire les concentrations de lipides et de triglycérides sériques ou hépatiques, l'inflammation hépatique et/ou l'insulinorésistance chez un patient, ladite formulation comprenant des micro-organismes vivants produisant de la féruloyl estérase seuls ou en association avec un excipient acceptable sur le plan pharmaceutique résistant aux conditions gastriques, et dans laquelle lesdits micro-organismes sont de type sauvage et/ou génétiquement modifiés. La présente invention concerne également une formulation orale conçue pour réduire les concentrations de lipides et de triglycérides sériques ou hépatiques, l'inflammation hépatique et/ou l'insulinorésistance chez un patient, ladite formulation comprenant des microcapsules polymères contenant des micro-organismes vivants produisant de la féruloyl estérase en suspension dans un excipient acceptable sur le plan pharmaceutique, lesdites microcapsules étant semi-perméables et résistantes aux conditions gastro-intestinales, et lesdits micro-organismes étant de type sauvage et/ou génétiquement modifiés, ainsi que des méthodes de prévention ou de traitement de maladies et de troubles hépatiques et des utilisations de celles-ci.

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