Plastin promoter directed gene therapy

Details Plastin promoter directed gene therapy Plastin promoter directed gene therapy

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) A01N 43/04 (2006.01) A61K 31/70 (2006.01) C12N 15/63 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2351641

The invention relates generally to the treatment of cancer using plastin promoter directed gene therapy. The invention includes vectors and recombinant viruses in which a plastin promotor is used to effect the expression of therapeutic transgenes in neoplastic but not in normal epithelial cells.

La présente invention concerne de façon générale le traitement du cancer en utilisant une thérapie génique dirigée par le promoteur de plastine. Cette invention comprend des vecteurs et des virus de recombinaison dans lesquels un promoteur de plastine est utilisé pour réaliser l'expression des transgènes thérapeutiques dans les néoplasies mais pas dans les cellules épithéliales normales.

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