C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/44 (2006.01) A61K 31/50 (2006.01)
Patent
CA 2319554
This invention discloses quinoxalinones according to Formula (I) or stereoisomers or pharmaceutically acceptable salts, esters, amides or prodrugs thereof, which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts and pro-drugs of the compounds, pharmaceutically acceptable compositions comprising the compounds, their salts or prodrugs, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnormal thrombosis.
L'invention concerne des quinoxalinones représentées par la formule (I), ou des stéréo-isomères ou leurs sels, esters, amides ou promédicaments pharmaceutiquement acceptables, lesquelles ont des effets inhibiteurs sur des sérines-protéases telles que le facteur Xa, la thrombine et le facteur VIIa. L'invention concerne également des sels et promédicaments pharmaceutiquement acceptables des composés, des compositions pharmaceutiquement acceptables contenant ces composés, leurs sels ou promédicaments, ainsi que des méthodes pour les utiliser comme agents thérapeutiques pour traiter ou prévenir chez des mammifères des états pathologiques caractérisés par une thrombose anormale.
Dudley Danette Andrea
Edmunds Jeremy John
Macrae & Co.
Warner-Lambert Company
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