Thiadiazoles as cxc- and cc- chemokine receptor ligands

Details Thiadiazoles as cxc- and cc- chemokine receptor ligands Thiadiazoles as cxc- and cc- chemokine receptor ligands

C - Chemistry, Metallurgy

07

D

C07D 285/10 (2006.01) A61K 31/433 (2006.01) A61K 31/4436 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2550189

Disclosed are novel compounds of Formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and ischemia reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of Formula (IA).

L'invention concerne de nouveaux composés représentés par la formule générale (IA) et leurs sels et solvates de qualité pharmaceutique. Le substituant A désigne un groupe hétéroaryle, aryle, hétérocycloalkyle, cycloalkyle, aryle, alcynyle, alcényle, aminoalkyle, alkyle ou amino. Le substituant B désigne un groupe aryle ou hétéroaryle. L'invention concerne également un procédé destinée au traitement de maladies induites par des chimiokines, telles que le cancer, l'angiogenèse, les maladies oculaires angiogéniques, les maladies pulmonaires, la sclérose en plaques, la polyarthrite rhumatoïde, l'ostéoarthrite, l'accident vasculaire cérébral et la lésion d'ischémie-reperfusion, la douleur (la douleur aiguë, la douleur inflammatoire aiguë et chronique et la douleur neuropathique, par exemple), utilisant un composé représenté par la formule générale (IA)

Affiliated with

Also associated with

Rating

Thiadiazoles as cxc- and cc- chemokine receptor ligands does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thiadiazoles as cxc- and cc- chemokine receptor ligands, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thiadiazoles as cxc- and cc- chemokine receptor ligands will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1490822