C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/74 (2006.01) A61K 31/44 (2006.01) A61K 31/50 (2006.01) C07D 213/64 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2315827
Selected novel substituted pyridine and pyridazine compounds are effective for prophylaxis and treatment of diseases, such as TNF-.alpha., IL-1.beta., IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, cancer, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
L'invention porte sur de nouveaux composés de pyridine et de pyridazine substituées utilisables pour la prophylaxie et le traitement de maladies telles que celles induites par le TNF- alpha l'IL-1 beta , l'IL-6 et/ou l'IL-8, et autres maladies telles que le cancer, la douleur et le diabète. L'invention englobe les nouveaux composés, leurs analogues, leurs bioprécurseurs et leurs sels pharmacocompatibles, ainsi que des procédés de prophylaxie et de traitement de maladies, troubles ou états compremant les inflammations, le cancer, la douleur, le diabète et autres; elle porte en outre sur les procédés d'obtention de ces composés et sur leurs intermédiaires de fabrication.
Hwang Chan Kou
Mantlo Nathan B.
Spohr Ulrike D.
Amgen Inc.
Gowling Lafleur Henderson Llp
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