Non-natural amino acid polypeptides having modulated...

Details Non-natural amino acid polypeptides having modulated... Non-natural amino acid polypeptides having modulated...

C - Chemistry, Metallurgy

12

N

C12N 9/10 (2006.01) C12N 15/12 (2006.01) C12N 15/54 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2636797

The present invention addresses, among other things, modulating the immunogenicity of polypeptides by substituting one or more non- naturally encoded amino acids for any one or more naturally occurring amino acids in the polypeptide or adding a non-natural amino acid, and also addresses the production of polypeptides with improved biological or pharmacological properties, such as improved therapeutic half-life or modulated immunogenicity.

L'invention concerne des polypeptides d'acides aminés non naturellement codés présentant une immunogénicité modulée ainsi que leur utilisation.

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