Oligonucleotide transfection screening method

Details Oligonucleotide transfection screening method Oligonucleotide transfection screening method

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 51/04 (2006.01) C07K 14/00 (2006.01) C12N 15/87 (2006.01) C12N 15/88 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2431219

Different-sequence peptoids, including lipid-and sterol-conjugated peptoids, are found to be effective in transfection of cells with oligonucleotides. Combinatorial libraries of such peptoids can be screened efficiently in a high- throughput format, and selected peptoids are identified post-screening.

L'invention concerne des peptoïdes à séquence différente, notamment des peptoïdes conjugués à un lipide et à un stérol, qui se sont avérés efficaces lors de la transfection de cellules avec des oligonucléotides. Des banques combinatoires contenant lesdits peptoïdes peuvent être criblées efficacement dans un format haut rendement et les peptoïdes sélectionnés peuvent être identifiés après le criblage.

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