Polymorphisms in the zf9 gene linked to a predisposition for...

Details Polymorphisms in the zf9 gene linked to a predisposition for... Polymorphisms in the zf9 gene linked to a predisposition for...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2439624

The present invention relates to an in vitro method for diagnosing or detecting a predisposition to a condition at least partially characterised by inappropriate fibrosis or scarring (e.g. Dupuytren's Disease). The method comprises examining the ZF9 gene, and regulatory elements thereof, derived from a subject of interest to detect the presence of a genetic poylmorphism or mutation in said gene which is linked with the condition.

La présente invention concerne une méthode <i>in vitro</i> pour diagnostiquer ou détecter une prédisposition à un état au moins partiellement caractérisé par une fibrose ou une cicatrisation inappropriée (p. ex. maladie de Dupuytren). Cette méthode consiste à examiner le gène ZF9 et les éléments régulateurs de ce dernier, sur un patient, afin de détecter la présence d'un polymorphisme ou d'une mutation génétique dans ledit gène associé à cet état.

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