Method and composition for treating tumors having high...

Details Method and composition for treating tumors having high... Method and composition for treating tumors having high...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 31/05 (2006.01) A61K 31/085 (2006.01) A61K 31/165 (2006.01) A61K 31/195 (2006.01) A61K 31/235 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2122922

Tumor cells which have .beta.-glucuronidase and tyrosinase activity are selectively treated by administration of a conjugate of a cytotoxic compound which is a substrate for tyrosinase and glucuronic acid or a pharmaceutically acceptable salt or ester thereof, particularly the triacetylated form of glucuronic acid. Among the cytotoxic phenolic compounds which are substrates for tyrosinase which can be used are tyrosine, 4-hydroxyanisole, butylated hydroxyanisole, L-3,4-dihydroxyphenylalanine, dopamine (3,4-dihydroxyphenethylamine), terbutylcatechol, hydroquinone, resorcinol, 6- hydroxydopa (3,4,6-trihydeoxyphenylalanine) and methyl gallate.

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