Orphan cytokine receptor

Details Orphan cytokine receptor Orphan cytokine receptor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2334042

The present invention provides for nucleic acid sequences that encode novel mammalian receptor polypeptides, designated OCR1. The invention also provides assay systems that may be used to detect and/or measure ligands that bind the MAMMALIAN OCR1 gene product. The present invention also provides for diagnostic and therapeutic methods based on the interaction between MAMMALIAN OCR1 and agents that initiate signal transduction through binding to MAMMALIAN OCR1. In a specific embodiment, the MAMMALIAN OCR1 may be HUMAN OCR1 or MOUSE OCR1.

L'invention concerne des séquences d'acides nucléiques codant de nouveaux polypeptides de récepteurs mammifères désignés OCR1. Elle concerne également des systèmes de dosage pouvant être mis en application afin de détecter et/ou de mesurer des ligands se fixant au produit génétique OCR1 MAMMIFERE (MAMMALIAN OCR1). Elle concerne également des procédés diagnostiques et thérapeutiques basés sur l'interaction entre OCR1 MAMMIFERE et des agents déclenchant la transduction d'un signal par fixation à OCR1 MAMMIFERE. Dans un mode de réalisation spécifique, OCR1 MAMMIFERE peut être OCR1 humain ou OCR1 murin.

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