Derivatives of piperidinylalkylcarbamates, preparation...

Details Derivatives of piperidinylalkylcarbamates, preparation... Derivatives of piperidinylalkylcarbamates, preparation...

C - Chemistry, Metallurgy

07

D

C07D 211/28 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/4468 (2006.01) C07D 207/09 (2006.01) C07D 211/58 (2006.01) C07D 401/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2554608

The invention relates to a compound having general formula (I), wherein: m = 1 to 4; n represents = 1, 2 or 3; o = 1 or 2; A is selected from among one or more X, Y and/or Z groups; X = optionally-substituted methylene; Y = C¿2?-alkenylene, optionally substituted; Z = C¿3-7?-cycloalkyl; B = covalent bond or C¿1-6?-alkylene; G = covalent bond, O, S, -CH(OH)-, CO, SO or SO¿2?; R¿1? represents an aryl- or heteroaryl-type group; R¿2 ?=hydrogen or C¿1?-¿6?-alkyl; R¿3? = hydrogen, C¿1-6?-alkyl, C¿3-7?-cycloalkyl, C¿3-7?-cycloalkyl-C¿1-3?-alkylene. The inventive compound takes the form of a base, an acid addition salt, a hydrate or a solvate. Said compounds are suitable for use as FAAH enzyme inhibitors.

Composé répondant à la formule générale (I): dans laquelle m = 1 à 4 ; n représente = 1, 2 ou 3 ; o =1 ou 2; A est choisi parmi un ou plusieurs groupes X, Y et/ou Z ; X = méthylène éventuellement substitué; Y = C2-alcènylène éventuellement substitué ; Z = C3-7-cycloalkyle ; B = liaison covalente ou C1- 6-alkylène ; G = liaison covalente, 0, S, -CH(OH)-, CO, SO ou SO2; R1 représente un groupe de type aryle ou hétéroaryle ; R2 =hydrogène ou C1- 6- alkyle ; R3 = hydrogène, C1-6-alkyle, C3-7-cycloalkyle, C3-7-cycloalkyle-C1-3- alkylène ; à l'état de base, de sel d'addition à un acide, d'hydrate ou de solvat. CES COMPOSES SONT UTILISES COMME INHIBITEURS DE L~ENZYME FAAH

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