Nalmefene di-ester prodrugs

Details Nalmefene di-ester prodrugs Nalmefene di-ester prodrugs

C - Chemistry, Metallurgy

07

D

C07D 489/08 (2006.01) A61K 31/485 (2006.01) A61P 25/32 (2006.01)

Patent

CA 2722243

The present invention relates to prodrugs of nalmefene of formula (I), pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of of substance abuse disorders such as alcohol abuse and alcohol dependence and impulse control disorders such as pathological gambling and addiction to shopping.

La présente invention porte sur des promédicaments du nalméfène de formule (I), sur des compositions pharmaceutiques comprenant ces composés, sur des procédés chimiques pour la fabrication de ces composés et sur leur utilisation dans le traitement de troubles d'abus de substances tels que l'abus d'alcool et la dépendance à l'alcool et des troubles de contrôle des impulsions tels que le jeu pathologique et la dépendance au shopping.

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