Non-nucleoside reverse transcriptase inhibitors i for...

Details Non-nucleoside reverse transcriptase inhibitors i for... Non-nucleoside reverse transcriptase inhibitors i for...

C - Chemistry, Metallurgy

07

D

C07D 249/12 (2006.01) A61K 31/4196 (2006.01) A61K 31/4245 (2006.01) A61K 31/433 (2006.01) A61P 31/18 (2006.01) C07D 271/113 (2006.01) C07D 285/13 (2006.01)

Patent

CA 2518437

This invention relates to novel heterocyclic compounds of formula (I) wherein R1- R4, X1 and X2 are as defined in the summary and pharmaceutically acceptable salts and solvates thereof, methods to inhibit or modulate Human Immunodeficiency Virus (HIV) reverse transcriptase with compounds of formula (I), pharmaceutical compositions containing of formula (I) admixed with at least one solvent, carrier or excipient and processes to prepare compounds of formula (I). The compounds are useful for treating disorders in which HIV and genetically related viruses are to implicated.

Cette invention concerne de nouveaux composés hétérocycliques de formule (I), dans laquelle R?1¿¿-?? ¿R?4¿, X?1¿ et X?2¿ sont tels que définis dans le résumé analytique; et des sels pharmaceutiquement acceptables et des solvats desdits composés. Elle concerne également des méthodes d'inhibition ou de modulation de la transcriptase inverse du virus de l'immunodéficience humaine (VIH) avec les composés de formule (I), des compositions pharmaceutiques contenant les composés de formule (I) mélangés avec au moins un solvant, un support ou un excipient; et des méthodes de préparation des composés de formule (I). Ces composés sont utiles pour le traitement de troubles impliquant le VIH et des virus génétiquement apparentés.

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