Production of a monoclonal antibody by a transgenic avian

Details Production of a monoclonal antibody by a transgenic avian Production of a monoclonal antibody by a transgenic avian

Category

C - Chemistry, Metallurgy

Subcategory

12

Subsubcategory

P

IPC codes

C12P 21/08 (2006.01) A01K 67/027 (2006.01) C07K 16/02 (2006.01) C07K 16/06 (2006.01) C12N 5/00 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01) C12N 15/90 (2006.01) C12P 21/02 (2006.01)

Type

Patent

Patent number

CA 2436754

Description

The present invention relates generally to novel methods of producing transgenic chickens that generate antibodies or immunoglobulin polypeptides in whites of eggs. More specifically, one embodiment of the present invention relates to methods of inserting immunoglobulin-encoding transgenes into avian sperm cells for transfer to ova to generate transgenic zygotes. The transgenes may include at least two immunoglobulin-encoding nucleic acid sequences and an internal ribosome entry site (IRES) that allow the immunoglobulin polypeptides to be expressed by chicken cells and hence in egg whites.

L'invention concerne de manière générale de nouveaux procédés de production de poulets transgéniques qui produisent des anticorps ou des polypeptides d'immunoglobuline dans le blanc d'oeuf. Plus spécifiquement, elle concerne dans une forme de réalisation des procédés d'insertion de transgènes codant pour les immunoglobulines dans des cellules de sperme aviaire en vue de leur transfert dans les ovules pour produire des zygotes transgéniques. Ces transgènes peuvent inclure au moins deux séquences d'acide nucléique codant pour les immunoglobulines et un site d'entrée interne des ribosomes (IRES), qui permettent l'expression des polypeptides d'immunoglobuline par des cellules de poulet, et, par conséquent, dans le blanc d'oeuf.

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