Preparation of sevoflurane with negligible water content

C - Chemistry – Metallurgy – 07 – C

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C07C 41/00 (2006.01)

Patent

CA 2605246

Provided is a sevoflurane anesthetic product which can remain substantially undegraded after long periods of storage, as well as a method for preparing the product. The product comprises sevoflurane in a glass container having a water content of less than 130 ppm. The method comprises drying sevoflurane having a water content of greater than 130 ppm to a water content les than 130 ppm. A preferred method of drying comprises contacting a sevoflurane composition having a water content of greater than 130 ppm with alumina- containing molecular sieves such that the water content is reduced to less than 130 ppm.

La présente invention concerne un produit anesthésiant sevoflurane qui peut rester sensiblement non dégradé après de longues périodes de stockage, ainsi qu'un procédé de préparation de ce produit. Ce produit comprend un sevoflurane dans un récipient en verre possédant un contenu en eau < 130 ppm. Ce procédé consiste à déshydrater un sevoflurane possédant un contenu en eau > 130 ppm en un contenu en eau inférieur 130 ppm. Un procédé préféré de déshydratation consiste à mettre en contact une composition de sevoflurane possédant un contenu en eau > 130 ppm avec des tamis moléculaires contenant de l'alumine de sorte que ce contenu en eau soit réduit à un contenu inférieur à 130 ppm.

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