C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/04 (2006.01) A61K 31/4188 (2006.01) C07D 491/14 (2006.01)
Patent
CA 2563759
The invention provides compounds of formula (1), in which R1 is hydrogen, halogen, 1-4C-alkyl, 3-7-Ccycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 1-4-alkoxy, 1-4C-alkoxy-1-4C-alkyl, 1-4C-alkoxycarbonyl, 2-4C-alkenyl, 2-4C-alkynyl, fluoro-1-4C-alkyl, fluoro-1-4C-alkoxy-1-4C-alkyl or hydroxy-1-4C-alkyl, R2 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 1-4C-alkoxy- 1-4C-alkyl, 2-4C-alkenyl, 2-4C-alkynyl, fluoro-1-4C-alkyl or hydroxy-1-4C- alkyl, R3 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C- alkyl, 1-4C-alkoxy-1-4C-alkyl, fluoro-1-4C-alkyl, fluoro-1-4C-alkoxy-1-4C- alkyl or hydroxy-1-4C-alkyl, R4 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C- cycloalkyl-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, fluoro-1-4C-alkyl, fluoro-1-4C- alkoxy-1-4C-alkyl, hydroxy-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkylcarbonyl, mono- or di-1-4C-alkylamino-1-4C-alkylcarbonyl or 1-4C-alkylcarbonyl or where R3 and R4 together form a methylen (-CH2-), an ethylen (-CH2-CH2-), a propylen (-CH2- CH2-CH2-) or an isopropylidene (-C(-CH3)2-) radical, R5 is hydrogen, halogen, 1-4C-alkyl or fluoro-1-4C-alkyl, R6 is hydrogen, halogen, 1-4C- alkyl or fluoro-1-4C-alkyl, and the salts of these compounds. The compounds inhibit the secretion of gastric acid.
La présente invention a trait à des composés de formule (1), dans laquelle: R1 est hydrogène, halogène, alkyle en C1-C4, cycloalkyle en C3-C7, cycloalkyle en C3-C7-alkyle en C1-C4, alcoxy en C1-C4, alcoxy en C1-C4, alkyle en C1-C4, alcoxycarbonyle en C1-C4, alcényle en C2-C4, alcynyle en C2-C4, fluoro-alkyle en C1-C4, fluoro-alcoxy en C1-C4-alkyle en C1-C4, ou hydroxy-alkyle en C1-C4; R2 est hydrogène, alkyle en C1-C4, cycloalkyle en C3-C7, cycloalkyle en C3-C7-alkyle en C1-C4, alcoxy en C1-C4-alkyle en C1-C4, alcényle en C2-C4, alcynyle en C2-C4, fluoro-alkyle en C1-C4 ou hydroxy-alkyle en C1-C4; R3 est hydrogène, alkyle en C1-C4, cycloalkyle en C3-C7, cycloalkyle en C3-C7-alkyle en C1-C4, alcoxy en C1-C4-alkyle en C1-C4, fluoro-alkyle en C1-C4, fluoro-alcoxy en C1-C4-alkyle en C1-C4, ou hydroxy-alkyle en C1-C4; R4 est hydrogène, alkyle en C1-C4, cycloalkyle en C3-C7, cycloalkyle en C3-C7-alkyle en C1-C4, alcoxy en C1-C4-alkyle en C1-C4, fluoro-alkyle en C1-C4, fluoro-alcoxy en C1-C4, alkyle en C1-C4, hydroxy-alkyle en C1-C4, alcoxy en C1-C4-alkylcarbonyle en C1-C4, mono- or di-alkylamino en C1-C4-alkylcarbonyle en C1-C4, ou alkylcarbonyle en C1-C4, ou lorsque R3 et R4forment ensemble un radical méthylèn (-CH2-), éthylèn (-CH2-CH2-), propylèn (-CH2-CH2-CH2-) ou isopropylidène (-C(-CH3)2-); R5 est hydrogène, halogène, alkyle en C1-C4, ou fluoro-alkyle en C1-C4; R6 est hydrogène, halogène, alkyle en C1-C4, ou fluoro-alkyle en C1-C4, et les sels de ces composés. Les composés sont inhibiteurs de la sécrétion de l'acide gastrique.
Altana Pharma Ag
Gowling Lafleur Henderson Llp
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