C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/88 (2006.01) A61K 31/33 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 239/94 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2691100
The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of AIk, AbI, Aurora- A, B-Raf, C- Raf, Bcr-Abl, BRK, BIk, Bmx, BTK, C-Kit, C-Raf, C-Src, EphB1, EphB2, EphB4, FGFR1, FGFR2, FGFR3, FLT1, Fms, Flt3, Fyn, FRK3, JAK2, KDR, Lck, Lyn, PDGFR.alpha., PDGFR.beta., PKC.alpha., p38, Src, SIK, Syk, Tie2 and TrkB kinases.
L'invention concerne des composés et leurs compositions pharmaceutiques, qui sont utiles en tant qu'inhibiteurs de protéines kinases, et des procédés destinés à utiliser de tels composés afin de traiter, d'améliorer ou de prévenir un état pathologique lié à une activité kinase anormale ou dérégulée. Dans certains modes de réalisation, l'invention propose des procédés destinés à utiliser de tels composés pour traiter, améliorer ou prévenir des maladies ou des troubles qui impliquent une activation anormale des kinases AIk, AbI, Aurora- A, B-Raf, C- Raf, Bcr-Abl, BRK, BIk, Bmx, BTK, C-Kit, C-Raf, C-Src, EphB1, EphB2, EphB4, FGFR1, FGFR2, FGFR3, FLT1, Fms, Flt3, Fyn, FRK3, JAK2, KDR, Lck, Lyn, PDGFRa, PDGFRß, PKCa, p38, Src, SIK, Syk, Tie2 et TrkB.
Gray Nathanael S.
He Yun
Nguyen Truc Ngoc
Sim Taebo
Wang Xing
Fetherstonhaugh & Co.
Irm Llc
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