Ocular tension depressant

Details Ocular tension depressant Ocular tension depressant

A - Human Necessities

61

K

A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01)

Patent

CA 2185524

An eye-drop ocular tension depressant and/or an eye-drop glaucoma remedy containing a compound represented by general formula (I), or a salt, ester and the like thereof, wherein: R1 represents alkyl, alkenyl, or R5-A-B- (R5 being H, alkyl, cycloalkyl or acyl; A being O or S; and B being a single bond or alkylene); R2 represents alkyl, alkenyl or -CR6R7R8 (R6 being OH or alkoxy; and R7 and R8 each being H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl or aralkyl); R3 represents COOH or -CONR9R10 (R9 and R10 being H or optionally substituted alkyl); and R4 represents COOH, COCOOH or tetrazolyl.

Réducteur de tension oculaire et/ou collyre de traitement du glaucome contenant un composé de formule générale (I) ou ses sels, esters et leurs pareils. Dans la formule (I) R?1¿ représente alkyle, alcényle ou R?5¿-A-B, (R?5¿ étant H, alkyle, cycloalkyle ou acyle; A étant O ou S; et B étant une liaison simple ou alkylène); R?2¿ représente alkyle, alcényle ou -CR?6¿R?7¿R?8¿, (R?6¿ étant OH ou alcoxy; et R?7¿et R?8¿ étant chacun H, alkyle, alcényle, alkynyle, cycloalkyle, aryle ou aralkyle); R?3¿ représente COOH ou -CONR?9¿R?10¿ (R?9¿ et R?10¿ étant H ou un alkyle éventuellement substitué; et R?4¿ représente COOH, COCOOH ou tétrazolyle.

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