Thiol derivatives with metallopeptidase inhibitory activity

Details Thiol derivatives with metallopeptidase inhibitory activity Thiol derivatives with metallopeptidase inhibitory activity

C - Chemistry, Metallurgy

07

C

C07C 327/32 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/265 (2006.01) A61K 31/33 (2006.01) A61K 38/05 (2006.01) C07C 323/60 (2006.01) C07D 213/56 (2006.01) C07D 261/08 (2006.01) C07D 263/32 (2006.01) C07D 275/02 (2006.01) C07D 277/30 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01) C07K 5/06 (2006.01)

Patent

CA 2210151

Compounds of formula (I) wherein R, R1, R2, R3, R4, m and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as active ingredients are described. The compounds of formula (I) are endowed with a mixed ACE-inhibitory and NEP-inhibitory activity and are useful in the treatment of cardiovascular diseases.

Composés de formule (I) où R, R1, R2, R3, R4, <u>m</u> et <u>n</u> ont les significations mentionnées dans la description; leurs procédés de préparation; et préparations pharmaceutiques dont ils constituent les principes actifs. Lesdits composés de la formule (I) sont dotés d'une activité mixte à inhibition ACE et NEP et s'avèrent utiles dans le traitement des maladies cardio-vasculaires.

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