A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/47 (2006.01) A61K 31/00 (2006.01) A61K 31/472 (2006.01) A61K 31/496 (2006.01) A61K 31/553 (2006.01) A61K 31/7076 (2006.01) A61K 38/55 (2006.01) C07K 14/46 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2392958
The present application is directed to the discovery that hedgehog gene products, and signal transduction pathways involving hedgehog, are involved in maturation of T lymphocytes. Certain aspects of the invention are directed to preparations of hedgehog polypeptides, agonists, antagonists, or other molecules which regulate patchedor smoothened signalling, and their uses as immunomodulatory agents.
La présente invention concerne la découverte selon laquelle les produits géniques Hedgehog et les voies de transduction de signal comprenant Hedgehog jouent un rôle dans la maturation des lymphocytes T. Certains aspects de cette invention concernent les préparations de polypeptides, d'agonistes, d'antagonistes ou d'autres molécules du Hedgehog qui régulent la signalisation du Patched et du Smoothened, ainsi que leur utilisation en tant qu'agents immunorégulateurs.
Borden Ladner Gervais Llp
Curis Inc.
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