C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/08 (2006.01) C07C 227/20 (2006.01) C07C 227/32 (2006.01) C07C 227/34 (2006.01) C07C 271/22 (2006.01) C12P 13/00 (2006.01) C12P 41/00 (2006.01)
Patent
CA 2631110
A process for the preparation of (S)(+)-3-(aminomethyl)-5- methylhexanoic acid (pregabalin) of formula (I) or a salt thereof, (see formula I) comprising the reaction of a compound of formula (II) (see formula II) with an alcohol ROH, in the presence or absence of enzyme, to give a compound of formula (III) as herein defined (see formula III) the transformation of a compound of formula (III) into a compound of formula (VI) or (VIII) as herein defined, (see formula VI) (see formula VIII) and the subsequent hydrolysis of a compound of formula (VI) or (VIII), to give pregabalin.
Allegrini Pietro
Mantegazza Simone
Pastorello Dario
Razzetti Gabriele
Riva Sergio
Dipharma Francis S.r.l.
Gowling Lafleur Henderson Llp
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