Methods for the development of a biomolecule assay

Details Methods for the development of a biomolecule assay Methods for the development of a biomolecule assay

G - Physics

01

N

G01N 33/68 (2006.01) G01N 30/72 (2006.01)

Patent

CA 2625781

The present teachings provide methods for the development of a mass spectrometric based assay for a protein in a sample using parent-daughter ion transition monitoring (PDITM). In various aspects, the present teachings provide methods for developing a mass spectrometric based assay for a protein in a sample without the use of a standard for the protein. In various embodiments, the sample comprises proteolytic fragments of a protein which is present in low abundance in the physiological fluid from which it is derived.

L'invention concerne des procédés permettant la mise au point d'une analyse par spectrométrie de masse d'une protéine dans un échantillon par surveillance de transition ionique parent-enfant ("parent-daughter ion transition monitoring" ou PDITM). Selon divers aspects, l'invention porte sur des procédés de mise au point d'une analyse par spectrométrie de masse d'une protéine dans un échantillon sans utilisation d'une norme pour la protéine. Dans divers modes de réalisation, l'échantillon comprend des fragments protéolytiques d'une protéine qui est présente, à faible abondance, dans le liquide physiologique dont elle est dérivée.

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