Piperazine derivatives

Details Piperazine derivatives Piperazine derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07D 233/54 (2006.01) C07D 235/06 (2006.01) C07D 271/06 (2006.01) C07D 295/084 (2006.01) C07D 295/125 (2006.01) C07D 401/10 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 413/10 (2006.01) C07D 413/14 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2052619

H-408-f ABSTRACT PIPERAZINE DERIVATIVES Compounds of formula Image (I) where A is an alkylene chain of 1 or 2 carbon atoms optionally substituted by one or more lower alkyl groups, R is hydrogen or lower alkyl, R1 is an aryl or heteroaryl radical, R2 is a mono- or bicyclic heterocyclic radical, R3 is hydrogen, lower alkyl or hydroxy and R4 is a aryl or heteroaryl radical, and their pharmaceutically acceptable acid addition salts are 5-HT1A binding agents which may be used, for example, for the treatment of CNS - disorders such as anxiety.

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