Novel imidazopyridine carbonitrile compounds

Details Novel imidazopyridine carbonitrile compounds Novel imidazopyridine carbonitrile compounds

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 5/48 (2006.01) A61P 17/06 (2006.01) A61P 19/08 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2385251

The present invention relates to a selective inhibitor of mammalian osteoclast cell activity, processes for its preparation and pharmaceutical compositions comprising the same as well as methods of treatment, where said selective inhibitor is administered to a human or animal patient. Said selective inhibitor has been found to inhibit vacuolar H+-ATPase, such as vacuolar H+- ATPase in osteoclast cells, whereby it is therapeutically efficient against physiological disorders involving bone resorption. In an embodiment of the present invention, said selective inhibitor comprises an imidazopyridine carbonitrile compound with general formula (I).

L'invention concerne un inhibiteur sélectif de l'activité d'ostéoclastes de mammifères, leurs procédés de préparation et des compositions pharmaceutiques les contenant, ainsi que des méthodes de traitement consistant à administrer ledit inhibiteur sélectif à un patient humain ou animal. On a constaté que ledit inhibiteur sélectif inhibe la H?+¿-ATPase vacuolaire dans les ostéoclastes, et qu'il est donc efficace, au plan thérapeutique, contre les troubles physiologiques impliquant la résorption osseuse. Dans un mode de réalisation de l'invention, ledit inhibiteur comprend un composé imidazopyridine carbonitrile de formule générale I.

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