A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/57 (2006.01) A61K 9/00 (2006.01) A61K 31/355 (2006.01) A61L 31/08 (2006.01) A61L 31/16 (2006.01) A61M 31/00 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2744906
The present invention is directed to progesterone-containing compositions and devices that can maintain opening of a body passageway. One aspect of the invention provides a therapeutically effective (e.g., relaxative, anti-oxidative, anti-restenotic, anti-angiogenic, and/or anti -thrombotic) composition or formulation containing progesterone and optionally vitamin E. Another aspect of the invention provides a drug eluting device with at least one coating layer comprising a progesterone composition that can minimize or eliminate inflammation, thrombosis, restenosis, neo-intimal hyperplasia, rupturing of vulnerable plaque, and/or other effects related to device implantation, treatment, or interaction. Other aspects of the invention provide for methods of using such compositions, formulations, and devices.
La présente invention concerne des dispositifs et des compositions contenant de la progestérone, qui se révèlent capables de maintenir ouvert un passage de l'organisme. Selon un aspect, l'invention concerne une composition ou une forme galénique efficace d'un point de vue thérapeutique (par exemple décontractante, antioxydante, anti-resténotique, anti-angiogénique et/ou anti-thrombotique), qui contient de la progestérone et, éventuellement, de la vitamine E. Selon un autre aspect, l'invention concerne un dispositif imprégné d'un médicament, comportant au moins une couche de revêtement comprenant une composition à base de progestérone pouvant minimiser ou éviter l'inflammation, la thrombose, la resténose, l'hyperplasie néo-intimale, la rupture des plaques les plus fragiles et/ou d'autres effets associés à l'implantation d'un dispositif, à un traitement impliquant un dispositif ou à l'interaction avec un dispositif. Selon d'autres aspects, l'invention concerne des procédés d'utilisation desdites compositions, formes galéniques et dispositifs.
Jackson Gregg A.
Riches Mckenzie & Herbert Llp
LandOfFree
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