C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/48 (2006.01) C07C 323/41 (2006.01) C07C 323/59 (2006.01)
Patent
CA 2084505
2084505 9117261 PCTABS00008 Compounds of formula (I), in which R1 is alkyl of 1 to 3 carbon atoms; R2 is -COX, wherein X is hydroxy, methyl, amino, thio, H-N-(alkyl of 1 to 3 carbon atoms), N-(alkyl of 1 to 3 carbon atoms)2, or halogen; R3 is a straight or branched chain alkyl of 10 to 25 carbon atoms, or a straight or branched chain alkene including polyunsaturated alkenes of 10 to 25 carbon atoms; and the alkali metal, alkaline earth metal, ammonium, and substituted ammonium salts thereof when R2 is -COOH, are substrates and/or inhibitors specifically for prenyl cysteine methyltransferase enzymes which catalyze the methyl transfer from S-adenosylmethionine to the C-termini of proteins and peptides with prenylated cysteine residues at their C-termini. The compounds, as substrates, are particularly suitable for use in assays for qualitatively or quantitatively detecting the farnesyl cysteine methyltransferase enzymes.
Stock Jeffry B.
Swabey Ogilvy Renault
Trustees Of Princeton University (the)
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