Transdermal system for sustained delivery of polypeptides

Details Transdermal system for sustained delivery of polypeptides Transdermal system for sustained delivery of polypeptides

A - Human Necessities

61

K

A61K 38/02 (2006.01) A61K 38/28 (2006.01) A61K 38/39 (2006.01) A61N 1/00 (2006.01) A61N 1/30 (2006.01) C07K 2/00 (2006.01) C07K 14/62 (2006.01) C07K 14/78 (2006.01)

Patent

CA 2547621

The present invention relates to a transdermal system for sustained delivery of high molecular weight hydrophilic drugs, especially peptide-, polypeptide- or protein-drugs and to methods of use thereof. The system comprises an apparatus that generates micro-channels in the skin of a subject in conjunction with a transdermal patch comprising at least one drug reservoir layer comprising a polymeric matrix and a therapeutic or immunogenic peptide, polypeptide or protein. The system provides sustained delivery of therapeutic or immunogenic agents, thereby achieving sustained therapeutic blood concentrations of these agents.

Cette invention porte sur un système transdermique pour administration prolongée de médicaments hydrophiles de poids moléculaire élevé, en particulier de médicaments à base de peptides, de polypeptides ou de protéines, ainsi que sur des procédés d'utilisation de ce système. Ce système comprend un appareil qui génère des microcanaux dans la peau d'un sujet, lequel appareil est utilisé conjointement à un timbre transdermique qui comprend au moins une couche réservoir de médicament comprenant une matrice polymère et un peptide, un polypeptide ou une protéine thérapeutique ou immunogène. Ce système assure une administration prolongée d'agents thérapeutiques ou immunogènes, ce qui permet d'obtenir des concentrations sanguines thérapeutiques prolongées de ces agents.

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