Indole derivatives and their use as mcp-1 antagonists

Details Indole derivatives and their use as mcp-1 antagonists Indole derivatives and their use as mcp-1 antagonists

C - Chemistry, Metallurgy

07

D

C07D 209/42 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61P 29/00 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2356898

A compound of formula (I) wherein R1 is hydrogen, halo or methoxy; R2 is hydrogen, halo, methyl, ethyl or methoxy; R3 is carboxy, tetrazolyl, or - CONHSO2R4 where R4 is methyl, ethyl, phenyl, 2,5-dimethylisoxazolyl or trifluoromethyl; T is -CH2- or -SO2-; and ring A is 3-chlorophenyl, 4- chlorophenyl, 3-trifluoromethylphenyl, 3,4-dichlorophenyl, 3,4-difluorophenyl, 3-fluoro-4-chlorophenyl, 3-chloro-4-fluorophenyl or 2,3-dichloropyrid-5-yl; or a pharmaceutically acceptable salt or prodrug thereof, as well as pharmaceutical compositions containing them are described and claimed. These compounds and compositions are useful in the treatment of disease mediated by monocyte chemoattractant protein-1 or RANTES (Regulated Upon Activation, Normal T-cell Expressed and Secreted), such as inflammatory disease.

L'invention concerne un composé de formule (I). Dans ladite formule, R?1¿ est hydrogène, halo ou méthoxy; R?2¿ est hydrogène, halo, méthyle, éthyle ou méthoxy; R?3¿ est carboxy, tétrazolyle, ou -CONHSO¿2?R?4¿, sachant que R?4¿ est méthyle, éthyle, phényle, 2,5-diméthylisoxazolyle or trifluorométhyle; T est -CH¿2?-ou -SO¿2?-; et la chaîne A est 3-chlorophényle, 4-chlorophényle, 3-trifluorométhylphényle, 3,4-dichlorophényle, 3,4-difluorophényle, 3-fluoro-4-chlorophényle, 3-chloro-4-fluorophényle ou 2,3-dichloropyrid-5-yle. On englobe les sels pharmaceutiquement acceptables de ce type de composé, ainsi que les promédicaments correspondants, et les compositions pharmaceutiques qui renferment lesdits composés. Les composés et les compositions considérés sont utiles pour le traitement des maladies dont la médiation est assurée par la protéine MCP-1 ou la chimiokine RANTES (de type contrôlé par l'activation, exprimé et sécrété par les lymphocytes T normaux), comme les maladies inflammatoires.

Affiliated with

Also associated with

Rating

Indole derivatives and their use as mcp-1 antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Indole derivatives and their use as mcp-1 antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indole derivatives and their use as mcp-1 antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1500246