Proteins producing an altered immunogenic response and...

Details Proteins producing an altered immunogenic response and... Proteins producing an altered immunogenic response and...

G - Physics

01

N

G01N 33/549 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2424720

The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein. Alternatively, T-cell epitopes are mutated to produce increased immunogenic reactions.

L'invention concerne de nouveaux procédés et compositions permettant de produire des compositions hyperallergéniques et hypoallergéniques. Plus précisément, l'invention consiste à neutraliser ou à réduire le pouvoir des lymphocytes T à reconnaître des épitopes et, par conséquent, à empêcher la sensibilisation d'un individu à la protéine. Dans un autre mode de réalisation, les épitopes de lymphocytes T sont modifiés afin de produire des réactions immunogènes plus importantes.

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