Photocrosslinked hydrogel blend surface coatings

C - Chemistry – Metallurgy – 08 – L

Patent

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Details

C08L 5/02 (2006.01)

Patent

CA 2560016

Hydrogel polymer blends including precursors and crosslinked forms of the compositions. The blends provide an improved approach to achieve high quality, uniform coatings with better commercial viability than other approaches including copolymerization. Applications include mass spectral analysis of biomolecular analytes such as proteins. Dextran and acrylamide systems are preferred. Benzophenone groups can be used as photocrosslinking groups. Photoinitiators are not needed. Functionalities which can selectively bind to biomolecular analytes are included.

La présente invention a trait à des mélanges polymériques d'hydrogels comportant des précurseurs et des formes réticulées des compositions. Les mélanges permettent une technique améliorée pour la réalisation de revêtements uniformes de grande qualité avec une viabilité commerciale supérieure à d'autres techniques comprenant la copolymérisation. Des utilisations comprennent l'analyse spectrale de masse d'analytes biomoléculaires tels que des protéines. Des systèmes à base de dextrane et d'acrylamide sont préférés. Des groupes benzophénone peuvent être utilisés en tant que groupes de photoreticulation. Des photoamorceurs ne sont pas nécessaires. Des fonctionnalités de liaison sélective à des analytes biomoléculaires sont comprises.

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