A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/26 (2006.01) A61K 9/19 (2006.01) A61K 47/18 (2006.01) A61K 47/36 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01)
Patent
CA 2301889
Provisions of a foam inhibitor which effectively inhibits foaming (bubbling) caused at the time of dissolving dry compositions and of a water-soluble dry composition which comprises the foam inhibitor. The form inhibitor is suitable for inhibiting foaming caused at the time of dissolving dry compositions comprising saccharide which contain a hydrophobic amino acid as essential ingredient; and the water-soluble dry composition contains pharmacologically active proteinaceous substance, saccharide and hydrophobic amino acid having the hydropathy index of about not less than 2, wherein the concentration of the hydrophobic amino acid is in the range of 0.05 wt.% to less than 40 wt.% based on the total amount of the dry composition.
Cette invention concerne des agents antimousse permettant d'inhiber sensiblement la formation de mousse qui se produit lors de la re-dissolution de compositions sèches. Cette invention concerne également des compositions sèches solubles dans l'eau qui contiennent ces agents antimousse. Ces agents antimousse contiennent, en qualité d'ingrédient principal, des acides aminés hydrophobes capables d'inhiber la formation de mousse qui se produit lors de la dissolution de compositions sèches contenant des saccharides. Ces compositions sèches et solubles dans l'eau contiennent des substances protéiniques actives sur le plan pharmaceutique, des saccharides, ainsi que des acides aminés hydrophobes ayant un indice d'hydrophobie d'au moins 2 environ. La teneur en acides aminés hydrophobes varie d'un minimum d'environ 0,05 % en poids à un maximum de 40 % en poids de la totalité de la composition sèche.
Odomi Masaaki
Yamashita Chikamasa
Marks & Clerk
Otsuka Pharmaceutical Co. Ltd.
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