Synergistic pharmaceutical composition useful for inhibiting...

A - Human Necessities – 61 – K

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A61K 45/06 (2006.01) A61P 27/02 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2736382

A synergic pharmaceutical composition, useful for inhibiting human or animal neovascularization (angiongenesis) of the cornea, retina and other organs, characterized in that it comprises, in a pharmaceutically acceptable vehicle or carrier: 60 to 90% in weight of Suramine, or the equivalent of one of the pharmaceutically acceptable salts thereof; and 40 to 10% of Bevacizumab; wherein said percentages are with respect to the sum of the weights of both active principles. Said synergic pharmaceutical composition is presented in the form of an composition injectable by endovenous, intravitreous or subconjunctival route, or in the form for topical administration.

L'invention concerne une composition pharmaceutique synergique, utile pour inhiber la néovascularisation (angiogenèse) cornéenne et rétinienne ainsi que d'autres organes de l'être humain ou de l'animal, caractérisée en ce qu'elle comprend, dans un véhicule ou un support pharmaceutiquement acceptable: 60 à 90% en poids de Suramina, ou l'équivalent d'un de ses sels pharmaceutiquement acceptable; et 40 à 10% en poids de Bevacizumab; ces pourcentages dépendent de la somme des poids de chacun des principes actifs. Cette composition pharmaceutique synergique se présente sous la forme d'une composition injectable par voie endoveineuse, intravitréenne ou sous-conjonctivale, ou sous une forme destinée à l'administration topique.

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